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desvenlafaxine will increase the amount or influence of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Watch. Desvenlafaxine inhibits CYP2D6; with bigger desvenlafaxine doses (ie, four hundred mg) lessen the CYP2D6 substrate dose by around fifty%; no dosage adjustment essential with desvenlafaxine doses seven consecutive times q